The drive from Prague to Weeze Airport takes about 8 hours via the German A3, A4 or A38 motorways. In Germany, you don't need a vignette for passenger vehicles, so despite the longer distance, you can still think about possibly driving to this airport. The cost of petrol for a return journey will be up to 147 eur.
Parking at the airport is available at €70 per week, prices on the airport website.